Bioactive ceramics, composites and coatings for skeletal repair
Prof Serena Best, Cambridge University
Tuesday Nov 6th, 2012 at 19:30
Joint event with Institution of Mechanical Engineers
Bone can be considered to be a composite structure over a number of different hierarchical length scales. However, despite the elegance of its structure, bone suffers from a number of degenerative diseases and, with an aging population world-wide, there is a need to find long term solutions for bone replacement.
Synthetic hydroxyapatite (Ca10(PO4)6(OH)2) has been of interest as an orthopaedic biomaterial for more than 40 years because of its chemical stability to bone material. Bone will bond directly to the material in its pure sintered form. One approach to bone repair has been to produce synthetic bone grafts more similar in composition to bone material than pure hydroxyapatite, hence containing ionic substitutions in the apatite crystal lattice to encourage more rapid bone repair. Work building on the ideas of biomimetic materials development and characterization is of prime importance and a number of developments are under way in the area of bioactive and biodegradable composites. The dimensions of the bioactive reinforcing phase can have a significant influence on the mechanical and biological performance of the materails. Bioactive coatings on metallic amd polymeric biomaterials using vacuum plasma spraying, electro hydrodynamic atomization and radio frequency magnetron sputtering are also being investigated to provide surfaces with a range of topographical amd compositional characteristics
The lecture will describe ideas and research activities in the area of ceramics, bioactive coatings, biodegradable composites and explore the prospects for a new generation of orthopaedic biomaterials.
The talk will be followed by a discussion and buffet.
Members and non-members are welcome.
|Osteoblast cells attaching on synthetic substituted hydroxyapatite|